Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+

Janice Aldrich-Wright, Craig Brodie, Edith C. Glazer, Nathan W. Luedtke, Lev Elson-Schwab, and Yitzhak Tor 

Abstract

Symmetrical homometallic dinuclear complexes of the type [{Ru(dpq)2}2(phenSOSphen)]4+, with a flexible 2-mercaptoethyl ether linker joining the two [Ru(dpq)2(phen)]2+-based sub-units, have DNA dissociation constants (Kd) in the nM range.

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