RNA-selective modification by a platinum(II) complex conjugated to amino- and guanidinoglycosides.

Jürgen Boer, Kenneth F. Blount, Nathan W. Luedtke, Lev Elson-Schwab, and Yitzhak Tor

Abstract

New Pt(II) conjugates of neomycin B and guanidinoneomycin B are found to generate site-specific, RNA-selective, covalent cross-links to the HIV-1 Rev Response Element. Both aminoglycosides and guanidinoglycosides impart RNA selectivity to the cis-Pt moiety, serving as an important precedent for the selective covalent modification of therapeutically relevant RNA targets.

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